A good night’s rest isn’t just shutting your eyes for a few hours—it should be rejuvenating and get you ready to attack the next day with unlimited energy. Dr. Andrew Huberman, a renowned neuroscientist, has contributed significantly to our understanding of sleep through his research.

In this article, we will provide a comprehensive overview of Huberman’s sleep cocktail, its components, scientific backing, and practical tips on how to integrate it into your nightly routine to achieve restful sleep.

Key Takeaways

  • Overview of Huberman’s Sleep Cocktail: Dr. Andrew Huberman, a neuroscientist and professor at Stanford University, has developed a sleep cocktail comprising natural supplements aimed at enhancing sleep quality. These include magnesium threonate or bisglycinate, apigenin, and theanine.
  • Usage Recommendations: For optimal results, magnesium should be taken 1-2 hours before bed, apigenin 30 minutes prior, and theanine about 30 minutes before bed. It’s essential to maintain consistency and adjust dosages as needed.
  • Monitoring and Adjusting: Start with lower doses to monitor the body’s response and adjust accordingly. Be aware of potential mild side effects such as gastrointestinal issues from magnesium or sedation from apigenin.
  • Lifestyle Integration: Enhancing sleep involves more than just supplements. Effective strategies include managing light exposure, especially in the morning, controlling caffeine intake to not disrupt the sleep-wake cycle, and maintaining a cool, quiet sleep environment.

Who is Andrew Huberman?

Andrew Huberman is a prominent figure in the field of neuroscience and psychology, with a rich academic background that includes a position as a professor at Stanford University. His research focuses extensively on brain function, neuroplasticity, and the neural mechanisms underlying visual and emotional responses. Huberman’s work extends into practical applications, particularly in how we can leverage our understanding of the brain to improve our daily lives, including enhancing sleep quality.

His influence in the scientific community is significant, with numerous peer-reviewed articles and a popular podcast that disseminates complex scientific concepts into actionable, understandable advice. In a few of his podcast episodes, he breaks down the different action steps to achieve perfect sleep including the use of specific sleep supplements to support better sleep.

What is Andrew Huberman’s Sleep Cocktail?

This “sleep cocktail” is by no means a magical concoction. It simply is a scientifically formulated blend of supplements recommended by Andrew Huberman to enhance sleep quality. Its primary goal is to help individuals falling asleep faster and achieve deeper, more restorative sleep. This sleep aid has gained popularity not just for its effectiveness but also for its reliance on natural components, making it an appealing choice for those wary of traditional sleep medications.

The Components of the Huberman Sleep Cocktail

The cocktail includes a mix of specific supplements, each chosen for their unique benefits to sleep and overall neurological health:

  1. Magnesium Threonate or Bisglycinate: These forms of magnesium are preferred for their high bioavailability and ability to cross the blood-brain barrier, enhancing their effectiveness in supporting sleep.
  2. Apigenin: This compound, extracted from chamomile, is known for its calming effects and its ability to facilitate the onset of sleep.
  3. Theanine: Commonly found in tea, theanine promotes relaxation without sedation, helping the mind unwind in preparation for sleep.
  4. Additional Supplements: Occasionally, other supplements like Glycine, GABA, and Myo-Inositol are recommended, especially on nights when falling asleep may be more challenging.

Scientific Basis of the Ingredients

Understanding how each component of the Andrew Huberman Sleep Cocktail contributes to better sleep involves delving into the scientific research behind them. Here’s how these ingredients work individually and synergistically to enhance the quality of sleep.

Magnesium and Its Benefits

Magnesium plays a pivotal role in many bodily functions, including the regulation of neurotransmitters that are directly involved in the sleep process. Specifically, Magnesium Threonate and Bisglycinate have been shown to be effective in improving sleep quality because they are better absorbed and can cross the blood-brain barrier.

This means they can directly affect brain function, helping to calm the nervous system and reduce neuronal excitability, which is crucial for transitioning to sleep. Research suggests that magnesium can help increase GABA levels, a neurotransmitter that promotes sleep and reduces anxiety.

The Role of Apigenin

Apigenin, a bioflavonoid extracted from chamomile, is another key component of the sleep cocktail. It is primarily known for its anxiolytic (anxiety-reducing) effects, which it achieves by binding to GABA receptors in the brain, much like magnesium.

This binding action helps decrease anxiety and initiate sleep by promoting a state of calm. Studies have demonstrated that apigenin can help shorten the time it takes to fall asleep and increase sleep duration, making it a valuable ingredient for those who struggle with sleep initiation and maintenance.

Benefits of Theanine

Theanine is an amino acid commonly found in tea leaves and is well-regarded for its ability to promote relaxation without sedation. It works by modulating aspects of brain function, primarily by increasing levels of GABA and other calming brain chemicals like serotonin and dopamine.

This modulation helps to balance the brain’s excitatory and inhibitory signals, providing a calming effect that prepares the mind for sleep. Clinical studies have shown that theanine can improve sleep quality not by acting as a sedative, but by reducing anxiety and promoting relaxation.

How to Use the Huberman Sleep Cocktail

To gain the maximum benefits from the Huberman Sleep Cocktail, it’s important to understand the optimal way to incorporate it into your nighttime routine. Here are some guidelines on how to use this sleep aid effectively:

Dosage and Timing

  1. Magnesium (Threonate or Bisglycinate): It’s recommended to take about 200-400 mg of magnesium. The best time to take magnesium is 1-2 hours before bed, as it helps your body and brain wind down and prepare for sleep.
  2. Apigenin: The suggested dosage for apigenin is around 50 mg. Since it’s derived from chamomile, you can take it in supplement form or as a strong chamomile tea approximately 30 minutes before bedtime.
  3. Theanine: A dosage of 100-200 mg of theanine can be effective. Like apigenin, it should be taken about 30 minutes before bed. Theanine works well when consumed close to bedtime because of its fast-acting relaxation effects.
  4. Additional Supplements: On nights when you might feel particularly stressed or anticipate difficulty sleeping, adding supplements like Glycine (around 3-5 grams) or GABA (100-200 mg) can be beneficial. These should also be taken approximately 30 minutes to an hour before bed.

Consistency Is Key

For the best results, consistency is crucial. Integrating the sleep cocktail into your nightly routine regularly helps your body establish a consistent rhythm, making it easier to fall asleep and wake up naturally refreshed. However, it’s important to listen to your body and adjust dosages or timing as needed based on your specific reactions to the supplements.

Monitoring Your Response

Each person’s body reacts differently to supplements. It’s advisable to start with lower doses of each component and gradually increase to the recommended dosage while monitoring how your body responds. If you experience any discomfort or adverse effects, adjusting the dosage or consulting with a healthcare provider would be wise.

Potential Side Effects and Considerations

While the Huberman Sleep Cocktail is composed of natural supplements known for their safety and efficacy, it’s important to be aware of potential side effects and considerations. Understanding these can help you use the sleep cocktail responsibly and effectively.

Side Effects

  1. Magnesium: Though generally well-tolerated, excessive intake of magnesium supplements can lead to gastrointestinal issues such as diarrhea or abdominal cramping. It’s important to adhere to the recommended dosage and adjust if necessary.
  2. Apigenin: While apigenin is safe for most people, in some cases, it can cause mild sedation. If you find the effect too strong, consider reducing the dosage.
  3. Theanine: Theanine is also well-tolerated, but high doses may lead to headaches or dizziness in sensitive individuals.
  4. Additional Supplements: Supplements like GABA and Glycine are usually safe, but high doses might cause mild side effects such as nausea, headaches, or digestive upset.


  • Pre-existing Health Conditions: If you have underlying health conditions or are taking other medications, it’s crucial to consult with a healthcare provider before starting any new supplement regimen. This is to ensure that the sleep cocktail components do not interact adversely with your medications or exacerbate health issues.
  • Pregnancy and Breastfeeding: If you are pregnant or breastfeeding, you should consult your healthcare provider before using the Huberman Sleep Cocktail or any of its components.
  • Long-term Use: While these supplements are beneficial for sleep, it’s advisable to consider their long-term use. Regularly reassess your need for the sleep cocktail and whether adjustments to the regimen are necessary.

Mitigating Side Effects

To minimize potential side effects, start with lower doses of each supplement and gradually increase to the recommended levels as you monitor your body’s response. This stepwise approach allows you to gauge how well you tolerate each component and adjust accordingly.

Lifestyle Tips for Better Sleep

Supplements are great, but they won’t magically overturn poor lifestyle habits. Dr. Andrew Huberman advocates for several lifestyle changes that can significantly improve your sleep quality. These changes focus on natural ways to regulate your sleep-wake cycle and create an optimal environment for restful sleep.

Light Exposure

One of the most critical factors in regulating sleep patterns is light exposure. Dr. Huberman emphasizes the importance of natural light exposure, particularly in the morning. Exposure to sunlight within the first hour of waking up can help reset your body’s circadian rhythm, which controls your sleep-wake cycle.

This exposure helps suppress melatonin production during the day, ensuring it rises at the right time in the evening to promote sleepiness. Additionally, limiting exposure to blue light from screens in the hours before bedtime is crucial as it can interfere with melatonin production and delay sleep onset.

Caffeine Management

Caffeine is a well-known stimulant that can affect sleep quality and the ability to fall asleep. Dr. Huberman recommends managing your caffeine intake by avoiding caffeine late in the day — typically recommended to stop caffeine consumption around 2 PM. This ensures that caffeine does not interfere with the natural buildup of adenosine, a chemical in the brain that promotes sleepiness as the day progresses.

Temperature and Environment

The sleep environment also plays a vital role in how well you sleep. Dr. Huberman points out that the ideal bedroom temperature for optimal sleep is between 60-67 degrees Fahrenheit (15.5-19.5 degrees Celsius). A cooler environment helps lower the body’s core temperature, signaling that it’s time to sleep. Furthermore, reducing noise and light pollution in your bedroom can enhance sleep quality. Consider using blackout curtains, eye masks, and white noise machines to create a more conducive sleeping environment.

Implementing these lifestyle tips in conjunction with the Huberman Sleep Cocktail can lead to significant improvements in your sleep quality. These changes not only support the effectiveness of the sleep cocktail but also enhance your overall health and well-being.

Earthly Threads: Your Family’s Sleep Partner

As we’ve explored various strategies and supplements to improve sleep, including the detailed guide on the Huberman Sleep Cocktail, it’s clear that optimizing sleep is a holistic process that can involve multiple elements.One such element is the environment in which you sleep. High-quality bedding and sleepwear can significantly enhance the comfort and quality of your sleep. Earthly Threads offers a range of bamboo pajamas and bamboo bedding that not only provide comfort but also help regulate body temperature, ensuring a cooler and more soothing sleep environment.

Marketing Team